<<<<<<< HEAD rgpv syllabus BPharm(PCI) Grading System 4th Semester 4030719011307-5d1a733b

BP401T. PHARMACEUTICAL ORGANIC CHEMISTRY –III (Theory)

Note: Emphasize on definition, types, mechanisms, examples, uses/applications UNIT-I

Stereo isomerism

Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds Elements of symmetry, chiral and achiral molecules. DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers

Reactions of chiral molecules

Racemic modification and resolution of racemic mixture. Asymmetric synthesis: partial and absolute

UNIT-II

Geometrical isomerism-Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems) Methods of determination of configuration of geometrical isomers. Conformational isomerism in Ethane, n-Butane and Cyclohexane.

Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity.Stereospecific and stereoselective reactions

UNIT-III

Heterocyclic compounds:

Nomenclature and classification, Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrrole, Furan, and Thiophene. Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene

UNIT-IV

Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrazole, Imidazole, Oxazole and Thiazole. Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives

UNIT-V

Reactions of synthetic importance

Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction, Oppenauer-oxidation and Dakin reaction, Beckmanns rearrangement and Schmidt rearrangement, Claisen-Schmidt condensation


Recommended Books (Latest Editions)

Organic chemistry by I.L. Finar, Volume-I & II.

A text book of organic chemistry – Arun Bahl, B.S. Bahl. Heterocyclic Chemistry by Raj K. Bansal

Organic Chemistry by Morrison and Boyd Heterocyclic Chemistry by T.L. Gilchrist

BP402T. MEDICINAL CHEMISTRY – I (Theory)

Study of the development of the following classes of drugs, Classification, mechanism of action, uses of drugs mentioned in the course, Structure activity relationship of selective class of drugs as specified in the course and synthesis of drugs superscripted (*)

UNIT- I

Introduction to Medicinal Chemistry. History and development of medicinal chemistry Physicochemical properties in relation to biological action

Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding,

Chelation, Bioisosterism, Optical and Geometrical isomerism.

Drug metabolism

Drug metabolism principles- Phase I and Phase II. Factors affecting drug metabolism including stereo chemical aspects.


UNIT- II

Drugs acting on Autonomic Nervous System Adrenergic Neurotransmitters:

Biosynthesis and catabolism of catecholamine. Adrenergic receptors (Alpha & Beta) and their distribution.

Sympathomimetic agents: SAR of Sympathomimetic agents

Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine, Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline.

Indirect acting agents: Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine. Agents with mixed mechanism: Ephedrine, Metaraminol.

Adrenergic Antagonists:

Alpha adrenergic blockers: Tolazoline*, Phentolamine, Phenoxybenzamine, Prazosin, Dihydroergotamine, Methysergide.

Beta adrenergic blockers: SAR of beta blockers, Propranolol*, Metibranolol, Atenolol, Betazolol, Bisoprolol, Esmolol, Metoprolol, Labetolol, Carvedilol.


UNIT-III

Cholinergic neurotransmitters:

Biosynthesis and catabolism of acetylcholine. Cholinergic receptors (Muscarinic & Nicotinic) and their distribution.

Parasympathomimetic agents: SAR of Parasympathomimetic agents

Direct acting agents: Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine.

Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible): Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.

Cholinesterase reactivator: Pralidoxime chloride.

Cholinergic Blocking agents: SAR of cholinolytic agents

Solanaceous alkaloids and analogues: Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.

Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*, Glycopyrrolate, Methantheline bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride.

UNIT- IV

Drugs acting on Central Nervous System

  1. Sedatives and Hypnotics:

    Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem. Barbiturtes: SAR of barbiturates, Barbital*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital. Miscelleneous: Amides & imides: Glutethmide, Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol, Aldehyde & their derivatives: Triclofos sodium, Paraldehyde.

  2. Antipsychotics

    Phenothiazeines: SAR of Phenothiazeines – Promazine hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride. Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine. Fluro buterophenones: Haloperidol, Droperidol, Risperidone. Beta amino ketones: Molindone hydrochloride. Benzamides: Sulpieride.

  3. Anticonvulsants: SAR of Anticonvulsants, mechanism of anticonvulsant action

    Barbiturates: Phenobarbitone, Methabarbital. Hydantoins: Phenytoin*, Mephenytoin, Ethotoin Oxazolidine diones: Trimethadione, Paramethadione Succinimides: Phensuximide, Methsuximide, Ethosuximide* Urea and monoacylureas: Phenacemide, Carbamazepine* Benzodiazepines: Clonazepam Miscellaneous: Primidone, Valproic acid , Gabapentin, Felbamate


    UNIT – V

    Drugs acting on Central Nervous System General anesthetics:

    Inhalation anesthetics: Halothane*, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane. Ultra short acting barbitutrates: Methohexital sodium*, Thiamylal sodium, Thiopental sodium. Dissociative anesthetics: Ketamine hydrochloride.*

    Narcotic and non-narcotic analgesics

    Morphine and related drugs: SAR of Morphine analogues, Morphine sulphate, Codeine, Meperidine hydrochloride, Anilerdine hydrochloride, Diphenoxylate hydrochloride, Loperamide hydrochloride, Fentanyl citrate*, Methadone hydrochloride*, Propoxyphene hydrochloride, Pentazocine, Levorphanol tartarate. Narcotic antagonists: Nalorphine hydrochloride, Levallorphan tartarate, Naloxone hydrochloride. Anti-inflammatory agents: Sodium salicylate, Aspirin, Mefenamic acid*, Meclofenamate, Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen*, Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone.


    Recommended Books (Latest Editions)

    Wilson and Giswold’s Organic medicinal and Pharmaceutical Chemistry. Foye’s Principles of Medicinal Chemistry.

    Burger’s Medicinal Chemistry, Vol I to IV.

    Introduction to principles of drug design- Smith and Williams. Remington’s Pharmaceutical Sciences.

    Martindale’s extra pharmacopoeia. Organic Chemistry by I.L. Finar, Vol. II.

    The Organic Chemistry of Drug Synthesis by Lednicer, Vol. 1-5. Indian Pharmacopoeia.

    Text book of practical organic chemistry- A.I.Vogel.

    BP406P. MEDICINAL CHEMISTRY – I (Practical)


    1. Preparation of drugs/ intermediates

      1,3-pyrazole, 1,3-oxazole, Benzimidazole, Benztriazole, 2,3- diphenyl quinoxaline, Benzocaine, Phenytoin, Phenothiazine, Barbiturate


    2. Assay of drugs

      Chlorpromazine, Phenobarbitone, Atropine, Ibuprofen, Aspirin, Furosemide


    3. Determination of Partition coefficient for any two drugs

BP 403 T. PHYSICAL PHARMACEUTICS-II (Theory)

UNIT-I

Colloidal dispersions: Classification of dispersed systems & their general characteristics, size & shapes of colloidal particles, classification of colloids & comparative account of their general properties. Optical, kinetic & electrical properties. Effect of electrolytes, coacervation, peptization& protective action.


UNIT-II

Rheology: Newtonian systems, law of flow, kinematic viscosity, effect of temperature, non- Newtonian systems, pseudoplastic, dilatant, plastic, thixotropy, thixotropy in formulation, determination of viscosity, capillary, falling Sphere, rotational viscometers

Deformation of solids: Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic Modulus


UNIT-III

Coarse dispersion: Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of flocculated and deflocculated suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Stability of emulsions, preservation of emulsions, rheological properties of emulsions and emulsion formulation by HLB method.

UNIT-IV

Micromeretics: Particle size and distribution, mean particle size, number and weight distribution, particle number, methods for determining particle size by different methods, counting and separation method, particle shape, specific surface, methods for determining surface area, permeability, adsorption, derived properties of powders, porosity, packing arrangement, densities, bulkiness & flow properties.


UNIT-V

Drug stability: Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate constants, determination of reaction order. Physical and chemical factors influencing the chemical degradation of pharmaceutical product: temperature, solvent, ionic strength, dielectric constant, specific & general acid base catalysis, Simple numerical problems. Stabilization of medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration dating of pharmaceutical dosage forms. Photolytic degradation and its prevention


Recommended Books: (Latest Editions)

Physical Pharmacy by Alfred Martin, Sixth edition Experimental pharmaceutics by Eugene, Parott.

Tutorial pharmacy by Cooper and Gunn.

Stocklosam J. Pharmaceutical calculations, Lea & Febiger, Philadelphia.

Liberman H.A, Lachman C., Pharmaceutical Dosage forms, Tablets, Volume-1 to 3, Marcel Dekkar Inc.

Liberman H.A, Lachman C, Pharmaceutical dosage forms. Disperse systems, volume 1, 2, 3. Marcel Dekkar Inc.

Physical Pharmaceutics by Ramasamy C, and Manavalan R.

BP 407P. PHYSICAL PHARMACEUTICS- II (Practical)

Determination of particle size, particle size distribution using sieving method Determination of particle size, particle size distribution using Microscopic method Determination of bulk density, true density and porosity

Determine the angle of repose and influence of lubricant on angle of repose


Determination of viscosity of liquid using Ostwald’s viscometer Determination sedimentation volume with effect of different suspending agent

Determination sedimentation volume with effect of different concentration of single suspending agent

Determination of viscosity of semisolid by using Brookfield viscometer Determination of reaction rate constant first order.

Determination of reaction rate constant second order Accelerated stability studies

BP 404 T. PHARMACOLOGY-I (Theory)


UNIT-I

General Pharmacology

Introduction to Pharmacology- Definition, historical landmarks and scope of pharmacology, nature and source of drugs, essential drugs concept and routes of drug administration, Agonists, antagonists( competitive and non competitive), spare receptors, addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy.

Pharmacokinetics- Membrane transport, absorption, distribution, metabolism and excretion of drugs .Enzyme induction, enzyme inhibition, kinetics of elimination

UNIT-II

General Pharmacology

Pharmacodynamics- Principles and mechanisms of drug action. Receptor theories

and classification of receptors, regulation of receptors. drug receptors interactions signal transduction mechanisms, G-protein–coupled receptors, ion channel receptor, transmembrane enzyme linked receptors, transmembrane JAK-STAT binding receptor and receptors that regulate transcription factors, dose response relationship, therapeutic index, combined effects of drugs and factors modifying drug action.

Adverse drug reactions. Drug interactions (pharmacokinetic and pharmacodynamic) Drug discovery and clinical evaluation of new drugs -Drug discovery phase, preclinical evaluation phase, clinical trial phase, phases of clinical trials and pharmacovigilance.

UNIT-III

Pharmacology of drugs acting on peripheral nervous system

Organization and function of ANS.

Neurohumoral transmission,co-transmission and classification of neurotransmitters. Parasympathomimetics, Parasympatholytics, Sympathomimetics, sympatholytics. Neuromuscular blocking agents and skeletal muscle relaxants (peripheral).

Local anesthetic agents.

Drugs used in myasthenia gravis and glaucoma


UNIT-IV

Pharmacology of drugs acting on central nervous system

Neurohumoral transmission in the C.N.S.special emphasis on importance of various neurotransmitters like with GABA, Glutamate, Glycine, serotonin, dopamine.

General anesthetics and pre-anesthetics.

Sedatives, hypnotics and centrally acting muscle relaxants. Anti-epileptics

Alcohols and disulfiram

UNIT-V

Pharmacology of drugs acting on central nervous system

Psychopharmacological agents: Antipsychotics, antidepressants, anti-anxiety agents, anti-manics and hallucinogens.

Drugs used in Parkinsons disease and Alzheimer’s disease. CNS stimulants and nootropics.

Opioid analgesics and antagonists

Drug addiction, drug abuse, tolerance and dependence.


Recommended Books (Latest Editions)

Rang H. P., Dale M. M., Ritter J. M., Flower R. J., Rang and Dale’s Pharmacology,.Churchil Livingstone Elsevier

Katzung B. G., Masters S. B., Trevor A. J., Basic and clinical pharmacology, Tata Mc Graw-Hill Goodman and Gilman’s, The Pharmacological Basis of Therapeutics

Marry Anne K. K., Lloyd Yee Y., Brian K. A., Robbin L.C., Joseph G. B., Wayne A. K., Bradley R.W., Applied Therapeutics, The Clinical use of Drugs, The Point Lippincott Williams & Wilkins

Mycek M.J, Gelnet S.B and Perper M.M. Lippincott’s Illustrated Reviews- Pharmacology

K.D.Tripathi. Essentials of Medical Pharmacology, JAYPEE Brothers Medical Publishers

(P) Ltd, New Delhi.

Sharma H. L., Sharma K. K., Principles of Pharmacology, Paras medical publisher Modern Pharmacology with clinical Applications, by Charles R.Craig& Robert,

Ghosh MN. Fundamentals of Experimental Pharmacology. Hilton & Company, Kolkata. Kulkarni SK. Handbook of experimental pharmacology. VallabhPrakashan,

BP 408 P.PHARMACOLOGY-I (Practical)

Introduction to experimental pharmacology.

Commonly used instruments in experimental pharmacology. Study of common laboratory animals.

Maintenance of laboratory animals as per CPCSEA guidelines.

Common laboratory techniques. Blood withdrawal, serum and plasma separation, anesthetics and euthanasia used for animal studies.

Study of different routes of drugs administration in mice/rats.

Study of effect of hepatic microsomal enzyme inducers on the phenobarbitone sleeping time in mice.

Effect of drugs on ciliary motility of frog oesophagus Effect of drugs on rabbit eye.

Effects of skeletal muscle relaxants using rota-rod apparatus. Effect of drugs on locomotor activity using actophotometer. Anticonvulsant effect of drugs by MES and PTZ method.

Study of stereotype and anti-catatonic activity of drugs on rats/mice. Study of anxiolytic activity of drugs using rats/mice.

Study of local anesthetics by different methods


Note: All laboratory techniques and animal experiments are demonstrated by simulated experiments by softwares and videos

BP 405 T.PHARMACOGNOSY AND PHYTOCHEMISTRY I (Theory)

UNIT-I


Introduction to Pharmacognosy:

Definition, history, scope and development of Pharmacognosy Sources of Drugs – Plants, Animals, Marine & Tissue culture

Organized drugs, unorganized drugs (dried latex, dried juices, dried extracts, gums and mucilages, oleoresins and oleo- gum -resins).

Classification of drugs:

Alphabetical, morphological, taxonomical, chemical, pharmacological, chemo and sero taxonomical classification of drugs

Quality control of Drugs of Natural Origin:

Adulteration of drugs of natural origin. Evaluation by organoleptic, microscopic, physical, chemical and biological methods and properties.

Quantitative microscopy of crude drugs including lycopodium spore method, leafconstants, camera lucida and diagrams of microscopic objects to scale with camera lucida.


UNIT-II

Cultivation, Collection, Processing and storage of drugs of natural origin:

Cultivation and Collection of drugs of natural origin Factors influencing cultivation of medicinal plants.

Plant hormones and their applications.Polyploidy, mutation and hybridization with reference to medicinal plants

Conservation of medicinal plants


UNIT-III

Plant tissue culture:

Historical development of plant tissue culture, types of cultures, Nutritional requirements, growth and their maintenance.

Applications of plant tissue culture in pharmacognosy. Edible vaccines


UNIT IV

Pharmacognosy in various systems of medicine:

Role of Pharmacognosy in allopathy and traditional systems of medicine namely, Ayurveda, Unani, Siddha, Homeopathy and Chinese systems of medicine.

Introduction to secondary metabolites:

Definition, classification, properties and test for identification of Alkaloids, Glycosides, Flavonoids, Tannins, Volatile oil and Resins

UNIT V

Study of biological source, chemical nature and uses of drugs of natural origin containing following drugs

Plant Products:

Fibers - Cotton, Jute, Hemp

Hallucinogens, Teratogens, Natural allergens

Primary metabolites:

General introduction, detailed study with respect to chemistry, sources, preparation, evaluation, preservation, storage, therapeutic used and commercial utility as Pharmaceutical Aids and/or Medicines for the following Primary metabolites: Carbohydrates: Acacia, Agar, Tragacanth, Honey Proteins and Enzymes : Gelatin, casein, proteolytic enzymes (Papain, bromelain, serratiopeptidase, urokinase, streptokinase, pepsin).Lipids(Waxes, fats, fixed oils) : Castor oil, Chaulmoogra oil, Wool Fat, Bees Wax Marine Drugs: Novel medicinal agents from marine sources


Recommended Books: (Latest Editions)

W.C.Evans, Trease and Evans Pharmacognosy, 16th edition, W.B. Sounders & Co., London, 2009. Tyler, V.E., Brady, L.R. and Robbers, J.E., Pharmacognosy, 9th Edn., Lea and Febiger, Philadelphia, 1988.

Text Book of Pharmacognosy by T.E. Wallis

Mohammad Ali. Pharmacognosy and Phytochemistry, CBS Publishers & Distribution, New Delhi.

Text book of Pharmacognosy by C.K. Kokate, Purohit, Gokhlae (2007), 37th Edition, Nirali Prakashan, New Delhi.

Herbal drug industry by R.D. Choudhary (1996), Ist Edn, Eastern Publisher, New Delhi. Essentials of Pharmacognosy, Dr.SH.Ansari, IInd edition, Birla publications, New Delhi, 2007 Practical Pharmacognosy: C.K. Kokate, Purohit, Gokhlae

Anatomy of Crude Drugs by M.A. Iyengar

BP409 P. PHARMACOGNOSY AND PHYTOCHEMISTRY I (Practical)

Analysis of crude drugs by chemical tests: (i)Tragaccanth (ii) Acacia (iii)Agar (iv) Gelatin (v) starch

(vi) Honey (vii) Castor oil

Determination of stomatal number and index

Determination of vein islet number, vein islet termination and paliside ratio. Determination of size of starch grains, calcium oxalate crystals by eye piece micrometer Determination of Fiber length and width

Determination of number of starch grains by Lycopodium spore method Determination of Ash value

Determination of Extractive values of crude drugs Determination of moisture content of crude drugs Determination of swelling index and foaming

======= rgpv syllabus BPharm(PCI) Grading System 4th Semester 4030719011307-5d1a733b

BP401T. PHARMACEUTICAL ORGANIC CHEMISTRY –III (Theory)

Note: Emphasize on definition, types, mechanisms, examples, uses/applications UNIT-I

Stereo isomerism

Optical isomerism – Optical activity, enantiomerism, diastereoisomerism, meso compounds Elements of symmetry, chiral and achiral molecules. DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers

Reactions of chiral molecules

Racemic modification and resolution of racemic mixture. Asymmetric synthesis: partial and absolute

UNIT-II

Geometrical isomerism-Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems) Methods of determination of configuration of geometrical isomers. Conformational isomerism in Ethane, n-Butane and Cyclohexane.

Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity.Stereospecific and stereoselective reactions

UNIT-III

Heterocyclic compounds:

Nomenclature and classification, Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrrole, Furan, and Thiophene. Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene

UNIT-IV

Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrazole, Imidazole, Oxazole and Thiazole. Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives

UNIT-V

Reactions of synthetic importance

Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction, Oppenauer-oxidation and Dakin reaction, Beckmanns rearrangement and Schmidt rearrangement, Claisen-Schmidt condensation


Recommended Books (Latest Editions)

Organic chemistry by I.L. Finar, Volume-I & II.

A text book of organic chemistry – Arun Bahl, B.S. Bahl. Heterocyclic Chemistry by Raj K. Bansal

Organic Chemistry by Morrison and Boyd Heterocyclic Chemistry by T.L. Gilchrist

BP402T. MEDICINAL CHEMISTRY – I (Theory)

Study of the development of the following classes of drugs, Classification, mechanism of action, uses of drugs mentioned in the course, Structure activity relationship of selective class of drugs as specified in the course and synthesis of drugs superscripted (*)

UNIT- I

Introduction to Medicinal Chemistry. History and development of medicinal chemistry Physicochemical properties in relation to biological action

Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding,

Chelation, Bioisosterism, Optical and Geometrical isomerism.

Drug metabolism

Drug metabolism principles- Phase I and Phase II. Factors affecting drug metabolism including stereo chemical aspects.


UNIT- II

Drugs acting on Autonomic Nervous System Adrenergic Neurotransmitters:

Biosynthesis and catabolism of catecholamine. Adrenergic receptors (Alpha & Beta) and their distribution.

Sympathomimetic agents: SAR of Sympathomimetic agents

Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine, Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline.

Indirect acting agents: Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine. Agents with mixed mechanism: Ephedrine, Metaraminol.

Adrenergic Antagonists:

Alpha adrenergic blockers: Tolazoline*, Phentolamine, Phenoxybenzamine, Prazosin, Dihydroergotamine, Methysergide.

Beta adrenergic blockers: SAR of beta blockers, Propranolol*, Metibranolol, Atenolol, Betazolol, Bisoprolol, Esmolol, Metoprolol, Labetolol, Carvedilol.


UNIT-III

Cholinergic neurotransmitters:

Biosynthesis and catabolism of acetylcholine. Cholinergic receptors (Muscarinic & Nicotinic) and their distribution.

Parasympathomimetic agents: SAR of Parasympathomimetic agents

Direct acting agents: Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine.

Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible): Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.

Cholinesterase reactivator: Pralidoxime chloride.

Cholinergic Blocking agents: SAR of cholinolytic agents

Solanaceous alkaloids and analogues: Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.

Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*, Glycopyrrolate, Methantheline bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride.

UNIT- IV

Drugs acting on Central Nervous System

  1. Sedatives and Hypnotics:

    Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem. Barbiturtes: SAR of barbiturates, Barbital*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital. Miscelleneous: Amides & imides: Glutethmide, Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol, Aldehyde & their derivatives: Triclofos sodium, Paraldehyde.

  2. Antipsychotics

    Phenothiazeines: SAR of Phenothiazeines – Promazine hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride. Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine. Fluro buterophenones: Haloperidol, Droperidol, Risperidone. Beta amino ketones: Molindone hydrochloride. Benzamides: Sulpieride.

  3. Anticonvulsants: SAR of Anticonvulsants, mechanism of anticonvulsant action

    Barbiturates: Phenobarbitone, Methabarbital. Hydantoins: Phenytoin*, Mephenytoin, Ethotoin Oxazolidine diones: Trimethadione, Paramethadione Succinimides: Phensuximide, Methsuximide, Ethosuximide* Urea and monoacylureas: Phenacemide, Carbamazepine* Benzodiazepines: Clonazepam Miscellaneous: Primidone, Valproic acid , Gabapentin, Felbamate


    UNIT – V

    Drugs acting on Central Nervous System General anesthetics:

    Inhalation anesthetics: Halothane*, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane. Ultra short acting barbitutrates: Methohexital sodium*, Thiamylal sodium, Thiopental sodium. Dissociative anesthetics: Ketamine hydrochloride.*

    Narcotic and non-narcotic analgesics

    Morphine and related drugs: SAR of Morphine analogues, Morphine sulphate, Codeine, Meperidine hydrochloride, Anilerdine hydrochloride, Diphenoxylate hydrochloride, Loperamide hydrochloride, Fentanyl citrate*, Methadone hydrochloride*, Propoxyphene hydrochloride, Pentazocine, Levorphanol tartarate. Narcotic antagonists: Nalorphine hydrochloride, Levallorphan tartarate, Naloxone hydrochloride. Anti-inflammatory agents: Sodium salicylate, Aspirin, Mefenamic acid*, Meclofenamate, Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen*, Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone.


    Recommended Books (Latest Editions)

    Wilson and Giswold’s Organic medicinal and Pharmaceutical Chemistry. Foye’s Principles of Medicinal Chemistry.

    Burger’s Medicinal Chemistry, Vol I to IV.

    Introduction to principles of drug design- Smith and Williams. Remington’s Pharmaceutical Sciences.

    Martindale’s extra pharmacopoeia. Organic Chemistry by I.L. Finar, Vol. II.

    The Organic Chemistry of Drug Synthesis by Lednicer, Vol. 1-5. Indian Pharmacopoeia.

    Text book of practical organic chemistry- A.I.Vogel.

    BP406P. MEDICINAL CHEMISTRY – I (Practical)


    1. Preparation of drugs/ intermediates

      1,3-pyrazole, 1,3-oxazole, Benzimidazole, Benztriazole, 2,3- diphenyl quinoxaline, Benzocaine, Phenytoin, Phenothiazine, Barbiturate


    2. Assay of drugs

      Chlorpromazine, Phenobarbitone, Atropine, Ibuprofen, Aspirin, Furosemide


    3. Determination of Partition coefficient for any two drugs

BP 403 T. PHYSICAL PHARMACEUTICS-II (Theory)

UNIT-I

Colloidal dispersions: Classification of dispersed systems & their general characteristics, size & shapes of colloidal particles, classification of colloids & comparative account of their general properties. Optical, kinetic & electrical properties. Effect of electrolytes, coacervation, peptization& protective action.


UNIT-II

Rheology: Newtonian systems, law of flow, kinematic viscosity, effect of temperature, non- Newtonian systems, pseudoplastic, dilatant, plastic, thixotropy, thixotropy in formulation, determination of viscosity, capillary, falling Sphere, rotational viscometers

Deformation of solids: Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic Modulus


UNIT-III

Coarse dispersion: Suspension, interfacial properties of suspended particles, settling in suspensions, formulation of flocculated and deflocculated suspensions. Emulsions and theories of emulsification, microemulsion and multiple emulsions; Stability of emulsions, preservation of emulsions, rheological properties of emulsions and emulsion formulation by HLB method.

UNIT-IV

Micromeretics: Particle size and distribution, mean particle size, number and weight distribution, particle number, methods for determining particle size by different methods, counting and separation method, particle shape, specific surface, methods for determining surface area, permeability, adsorption, derived properties of powders, porosity, packing arrangement, densities, bulkiness & flow properties.


UNIT-V

Drug stability: Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate constants, determination of reaction order. Physical and chemical factors influencing the chemical degradation of pharmaceutical product: temperature, solvent, ionic strength, dielectric constant, specific & general acid base catalysis, Simple numerical problems. Stabilization of medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability testing in expiration dating of pharmaceutical dosage forms. Photolytic degradation and its prevention


Recommended Books: (Latest Editions)

Physical Pharmacy by Alfred Martin, Sixth edition Experimental pharmaceutics by Eugene, Parott.

Tutorial pharmacy by Cooper and Gunn.

Stocklosam J. Pharmaceutical calculations, Lea & Febiger, Philadelphia.

Liberman H.A, Lachman C., Pharmaceutical Dosage forms, Tablets, Volume-1 to 3, Marcel Dekkar Inc.

Liberman H.A, Lachman C, Pharmaceutical dosage forms. Disperse systems, volume 1, 2, 3. Marcel Dekkar Inc.

Physical Pharmaceutics by Ramasamy C, and Manavalan R.

BP 407P. PHYSICAL PHARMACEUTICS- II (Practical)

Determination of particle size, particle size distribution using sieving method Determination of particle size, particle size distribution using Microscopic method Determination of bulk density, true density and porosity

Determine the angle of repose and influence of lubricant on angle of repose


Determination of viscosity of liquid using Ostwald’s viscometer Determination sedimentation volume with effect of different suspending agent

Determination sedimentation volume with effect of different concentration of single suspending agent

Determination of viscosity of semisolid by using Brookfield viscometer Determination of reaction rate constant first order.

Determination of reaction rate constant second order Accelerated stability studies

BP 404 T. PHARMACOLOGY-I (Theory)


UNIT-I

General Pharmacology

Introduction to Pharmacology- Definition, historical landmarks and scope of pharmacology, nature and source of drugs, essential drugs concept and routes of drug administration, Agonists, antagonists( competitive and non competitive), spare receptors, addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy.

Pharmacokinetics- Membrane transport, absorption, distribution, metabolism and excretion of drugs .Enzyme induction, enzyme inhibition, kinetics of elimination

UNIT-II

General Pharmacology

Pharmacodynamics- Principles and mechanisms of drug action. Receptor theories

and classification of receptors, regulation of receptors. drug receptors interactions signal transduction mechanisms, G-protein–coupled receptors, ion channel receptor, transmembrane enzyme linked receptors, transmembrane JAK-STAT binding receptor and receptors that regulate transcription factors, dose response relationship, therapeutic index, combined effects of drugs and factors modifying drug action.

Adverse drug reactions. Drug interactions (pharmacokinetic and pharmacodynamic) Drug discovery and clinical evaluation of new drugs -Drug discovery phase, preclinical evaluation phase, clinical trial phase, phases of clinical trials and pharmacovigilance.

UNIT-III

Pharmacology of drugs acting on peripheral nervous system

Organization and function of ANS.

Neurohumoral transmission,co-transmission and classification of neurotransmitters. Parasympathomimetics, Parasympatholytics, Sympathomimetics, sympatholytics. Neuromuscular blocking agents and skeletal muscle relaxants (peripheral).

Local anesthetic agents.

Drugs used in myasthenia gravis and glaucoma


UNIT-IV

Pharmacology of drugs acting on central nervous system

Neurohumoral transmission in the C.N.S.special emphasis on importance of various neurotransmitters like with GABA, Glutamate, Glycine, serotonin, dopamine.

General anesthetics and pre-anesthetics.

Sedatives, hypnotics and centrally acting muscle relaxants. Anti-epileptics

Alcohols and disulfiram

UNIT-V

Pharmacology of drugs acting on central nervous system

Psychopharmacological agents: Antipsychotics, antidepressants, anti-anxiety agents, anti-manics and hallucinogens.

Drugs used in Parkinsons disease and Alzheimer’s disease. CNS stimulants and nootropics.

Opioid analgesics and antagonists

Drug addiction, drug abuse, tolerance and dependence.


Recommended Books (Latest Editions)

Rang H. P., Dale M. M., Ritter J. M., Flower R. J., Rang and Dale’s Pharmacology,.Churchil Livingstone Elsevier

Katzung B. G., Masters S. B., Trevor A. J., Basic and clinical pharmacology, Tata Mc Graw-Hill Goodman and Gilman’s, The Pharmacological Basis of Therapeutics

Marry Anne K. K., Lloyd Yee Y., Brian K. A., Robbin L.C., Joseph G. B., Wayne A. K., Bradley R.W., Applied Therapeutics, The Clinical use of Drugs, The Point Lippincott Williams & Wilkins

Mycek M.J, Gelnet S.B and Perper M.M. Lippincott’s Illustrated Reviews- Pharmacology

K.D.Tripathi. Essentials of Medical Pharmacology, JAYPEE Brothers Medical Publishers

(P) Ltd, New Delhi.

Sharma H. L., Sharma K. K., Principles of Pharmacology, Paras medical publisher Modern Pharmacology with clinical Applications, by Charles R.Craig& Robert,

Ghosh MN. Fundamentals of Experimental Pharmacology. Hilton & Company, Kolkata. Kulkarni SK. Handbook of experimental pharmacology. VallabhPrakashan,

BP 408 P.PHARMACOLOGY-I (Practical)

Introduction to experimental pharmacology.

Commonly used instruments in experimental pharmacology. Study of common laboratory animals.

Maintenance of laboratory animals as per CPCSEA guidelines.

Common laboratory techniques. Blood withdrawal, serum and plasma separation, anesthetics and euthanasia used for animal studies.

Study of different routes of drugs administration in mice/rats.

Study of effect of hepatic microsomal enzyme inducers on the phenobarbitone sleeping time in mice.

Effect of drugs on ciliary motility of frog oesophagus Effect of drugs on rabbit eye.

Effects of skeletal muscle relaxants using rota-rod apparatus. Effect of drugs on locomotor activity using actophotometer. Anticonvulsant effect of drugs by MES and PTZ method.

Study of stereotype and anti-catatonic activity of drugs on rats/mice. Study of anxiolytic activity of drugs using rats/mice.

Study of local anesthetics by different methods


Note: All laboratory techniques and animal experiments are demonstrated by simulated experiments by softwares and videos

BP 405 T.PHARMACOGNOSY AND PHYTOCHEMISTRY I (Theory)

UNIT-I


Introduction to Pharmacognosy:

Definition, history, scope and development of Pharmacognosy Sources of Drugs – Plants, Animals, Marine & Tissue culture

Organized drugs, unorganized drugs (dried latex, dried juices, dried extracts, gums and mucilages, oleoresins and oleo- gum -resins).

Classification of drugs:

Alphabetical, morphological, taxonomical, chemical, pharmacological, chemo and sero taxonomical classification of drugs

Quality control of Drugs of Natural Origin:

Adulteration of drugs of natural origin. Evaluation by organoleptic, microscopic, physical, chemical and biological methods and properties.

Quantitative microscopy of crude drugs including lycopodium spore method, leafconstants, camera lucida and diagrams of microscopic objects to scale with camera lucida.


UNIT-II

Cultivation, Collection, Processing and storage of drugs of natural origin:

Cultivation and Collection of drugs of natural origin Factors influencing cultivation of medicinal plants.

Plant hormones and their applications.Polyploidy, mutation and hybridization with reference to medicinal plants

Conservation of medicinal plants


UNIT-III

Plant tissue culture:

Historical development of plant tissue culture, types of cultures, Nutritional requirements, growth and their maintenance.

Applications of plant tissue culture in pharmacognosy. Edible vaccines


UNIT IV

Pharmacognosy in various systems of medicine:

Role of Pharmacognosy in allopathy and traditional systems of medicine namely, Ayurveda, Unani, Siddha, Homeopathy and Chinese systems of medicine.

Introduction to secondary metabolites:

Definition, classification, properties and test for identification of Alkaloids, Glycosides, Flavonoids, Tannins, Volatile oil and Resins

UNIT V

Study of biological source, chemical nature and uses of drugs of natural origin containing following drugs

Plant Products:

Fibers - Cotton, Jute, Hemp

Hallucinogens, Teratogens, Natural allergens

Primary metabolites:

General introduction, detailed study with respect to chemistry, sources, preparation, evaluation, preservation, storage, therapeutic used and commercial utility as Pharmaceutical Aids and/or Medicines for the following Primary metabolites: Carbohydrates: Acacia, Agar, Tragacanth, Honey Proteins and Enzymes : Gelatin, casein, proteolytic enzymes (Papain, bromelain, serratiopeptidase, urokinase, streptokinase, pepsin).Lipids(Waxes, fats, fixed oils) : Castor oil, Chaulmoogra oil, Wool Fat, Bees Wax Marine Drugs: Novel medicinal agents from marine sources


Recommended Books: (Latest Editions)

W.C.Evans, Trease and Evans Pharmacognosy, 16th edition, W.B. Sounders & Co., London, 2009. Tyler, V.E., Brady, L.R. and Robbers, J.E., Pharmacognosy, 9th Edn., Lea and Febiger, Philadelphia, 1988.

Text Book of Pharmacognosy by T.E. Wallis

Mohammad Ali. Pharmacognosy and Phytochemistry, CBS Publishers & Distribution, New Delhi.

Text book of Pharmacognosy by C.K. Kokate, Purohit, Gokhlae (2007), 37th Edition, Nirali Prakashan, New Delhi.

Herbal drug industry by R.D. Choudhary (1996), Ist Edn, Eastern Publisher, New Delhi. Essentials of Pharmacognosy, Dr.SH.Ansari, IInd edition, Birla publications, New Delhi, 2007 Practical Pharmacognosy: C.K. Kokate, Purohit, Gokhlae

Anatomy of Crude Drugs by M.A. Iyengar

BP409 P. PHARMACOGNOSY AND PHYTOCHEMISTRY I (Practical)

Analysis of crude drugs by chemical tests: (i)Tragaccanth (ii) Acacia (iii)Agar (iv) Gelatin (v) starch

(vi) Honey (vii) Castor oil

Determination of stomatal number and index

Determination of vein islet number, vein islet termination and paliside ratio. Determination of size of starch grains, calcium oxalate crystals by eye piece micrometer Determination of Fiber length and width

Determination of number of starch grains by Lycopodium spore method Determination of Ash value

Determination of Extractive values of crude drugs Determination of moisture content of crude drugs Determination of swelling index and foaming

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